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Information × Registration Number 0221U105929, 0118U000953 , R & D reports Title Study of daily biorhythmic properties of the main pathogens of purulent-inflammatory diseases of children in order to develop a flexible antimicrobial strategy popup.stage_title Head Davydenko Viacheslav B, д.мед.н. Registration Date 13-09-2021 Organization Kharkiv National Medical University popup.description2 The ordering of the daily dynamics of the activity of pathogenicity factors St. aureus and E. coli as evidence of their adaptive response and formation of polyresistance. Levofloxacin was most effective in inhibiting pathogen growth and biofilm formation at 6:00 and 18:00. Decreases in the production of planktonic cells by clinical strains were registered 4 h after the action of antibiotics, and dense biofilms were formed on the 5th day. The established density of biofilms was probably higher in older groups of children and in the chronic course of the inflammatory process. Ozone-ultrasonic treatment of pathogenic microflora isolates effectively destroyed the formed biological films and prevented the formation of secondary biofilms Product Description popup.authors Mishyna Maryna Mitrofanivna Shtyker Stanislav Yurievich popup.nrat_date 2021-09-13 Close