Search academic texts

Information × Registration Number 0221U106004, 0118U004955 , R & D reports Title Study of natural and synthetic oligonucleotides as potential inhibitors of PD1 ligand-PD-L1 receptor interaction popup.stage_title Head Tkachuk Zenovii Yu, Кандидат біологічних наукTukalo Mykhailo A, Доктор біологічних наук Registration Date 22-09-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2  The aim of the project was to create an active pharmaceutical ingredient (API) on the basis of which it is possible to create effective antitumor drugs. Such antitumor APIs must have the ability to inhibit the binding of PDL1 ligand protein to the PD1 receptor of killer T cells. The study began with the selection of the most effective oligoribonucleotides (ORNs) and oligodeoxynucleotides (ODNs) and their analogs capable of preventing the binding of the PDL1 ligand protein to the PD1 receptor. In the second stage, plasmids with the corresponding genes were created and a sufficient amount of recombinant PD1 and PDL1 proteins were isolated. Preparative amounts of OH and their analogs have also been developed and their ability to interact with human PDL1 ligand-protein and PD1 receptor has been studied. Finally, OH inhibitors of PDL1 ligand-protein binding to the PD1 receptor of killer T lymphocytes were selected. Product Description popup.authors Gudzera Olga Yo Marchyshak Tetiana V. Melnichuk Nataliia S. Nikolaiev Roman O. Tkachuk Zenoviy Yuriyovych Tkachuk Larysa V. Tukalo Mykhailo A Yakovenko Tetiana H. popup.nrat_date 2021-09-22 Close