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Information × Registration Number 0221U106078, 0116U004046 , R & D reports Title Internal organs' diseases: predictors of development, optimization, diagnostics, treatment and prevention popup.stage_title Head Prystupa Liudmyla N., Доктор медичних наук Registration Date 07-10-2021 Organization Sumy State University popup.description2 The purpose of the research was to study the influence of genetic factors on the occurrence and course of diseases of internal organs, as well as on the effectiveness of treatment to increase its effectiveness. Research methods: general clinical, laboratory, instrumental, anthropometric, genetic and statistical analysis (SPSS Statistics 21.0). The higher risk of development and lower clinical efficacy of basic treatment of bronchial asthma depending on Gln27Glu polymorphism of the β2-adrenoceptor gene have been proved, the expediency of tiotropium bromide applying has been substantiated and its higher efficacy compared to formoterol in Gln27Glu-carriers has been confirmed. It has been established that one of the reasons for the progression of nonalcoholic fatty liver disease is hyperhomocysteinemia, which is genetically determined by C677T polymorphism of the methylenetetrahydrofolate reductase gene. Studies of the polymorphism of the MTHFR, MTR, and MTRR genes involved in homocysteine metabolism may be relevant for predicting the onset and progression of nonalcoholic fatty liver disease. The obtained results are introduced into the scientific and educational activities of the departments of therapeutic orientation of higher educational medical institutions, as well as into the medical work of medical and preventive institutions of our state. The most important data on the practical significance: taking into account the genotype in terns of Gln27Glu polymorphism of β2-adrenergic receptors gene can increase the efficiency of management of patients with bronchial asthma by adding tiotropium bromide to the basic treatment; correction of hyperhomocysteinemia depending on C677T polymorphism of the methylenetetrahydro-folate reductase gene increases the effectiveness of treatment of patients with non-alcoholic fatty liver disease in combination with type 2 diabetes mellitus. Product Description popup.authors Prystupa Liudmyla N. popup.nrat_date 2021-10-07 Close