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Information × Registration Number 0221U106199, 0120U104687 , R & D reports Title Study of the therapeutic effectiveness and safety of new equivalents of the dermis with the inclusion of a composite (the drug izatizon and the cytokine EMAP II) for the treatment of traumatic skin lesions popup.stage_title Head Lukash Liubov L., Доктор біологічних наук Registration Date 04-11-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 The main goal of the whole project is to create a new biotechnological product: dermis equivalents with the inclusion of a complex of biologically active substances synthesized by stem cells and a pharmaceutical composite (isatizon and cytokine EMAP II), as well as studies of their therapeutic efficacy and safety in vivo. The main tasks of the first stage of 2021 are the development of complexes of biologically active components of new equivalents of the dermis and conducting preclinical studies to determine their safety. The manifestations of possible acute and subchronic toxicity of biologically active complexes, which are the basis of a new biotechnological product, when introduced into the body of model animals. Research methods: in vitro culture, experiments on model animals in vivo, pathophysiological, biochemical, statistical. At the intermediate stage of this year, samples of biologically active components of new dermis equivalents and their complexes were developed (biologically active substances synthesized by stem cells and a pharmaceutical composite that includes the drug isatizon and the cytokine EMAP II). It was found that samples of biologically active complexes do not show obvious signs of acute and subchronic toxicity when administered to animals compared with the corresponding controls. No animal mortality and no signs of acute toxicity were observed even at the highest doses. Thus, a new biotechnological product (dermis equivalent) has been created, effective and safe, which has no world analogues and can be offered for the treatment of traumatic skin injuries. Product Description popup.authors Zaika Leonid A. Kolomiiets Lesia A. Kornelyuk Olexander Ivanovych Macewicz Larysa Leonidivna Papuga Alexander Yevgeniiovych Ruban Tetyana P. popup.nrat_date 2021-11-04 Close