Search academic texts

Information × Registration Number 0221U106309, 0121U113959 , R & D reports Title Assessment of bone metabolism, enteric nervous system, structure and enzymatic activity of gastrointestinal tract and oxidative stress in vertebrate after exposure to mycotoxins fumonisins in the prenatal period popup.stage_title Head Kotsiumbas Ihor Ya., Доктор ветеринарних наук Registration Date 23-11-2021 Organization State Scientific and Research Control Institute for Veterinary Medicinal Products and Feed Additives popup.description2  Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalisation in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins. Nutrition has a significant effect on both human and animal health. Improper preparation and storage of feed can result not only in significant economic losses, but also in the development of health problems in consumers. Cereal, commonly used in human and animal nutrition, regardless of the form of processing, in favorable climatic conditions, may be contaminated with fungi. Among the mycotoxins produced by fungi is Fusarium. The naturally occurring secondary products of the metabolism of Fusarium are mycotoxins called fumonisins. There are various types of fumonisins, including types A, B, C and P (F), which like other mycotoxins are heat-resistant metabolites. Type B fumonisins (FB1 and FB2) occur frequently and are very toxic. FB interfere with sphin-golipid metabolism. Both FB1 and FB2 were found in over 50% of samples of feed and feed raw materials . Both types of FB have a similar toxicity and occur naturally in a ratio of FB1 to FB2 of about 3:1. The presence of FB1 and FB2 in human or animal feed is regulated by EU legislation. The development of clinical signs of FB intoxi-cation depends on the dose of FB to which one is exposed. The various clinical implica-tions differ between animal species and are also dependent on the rout of FB admin-istration, as well as the sex and age of the animals. Horses, pigs, sheep and rodents are more sensitive to FB compared to other animals and display non-species specific symptoms, including hepatic or kidney toxicity, as well as some species specific symptoms on target organs (like the brain in horses and the lungs or esophagus in swine) . Product Description popup.authors Brezvyn Оksana M Kotsiumbas Ihor Ya Kuscnir Volodymyr I Levytskij Taras R Muzyka Viktor P Rudyk Halina V popup.nrat_date 2021-11-23 Close