Search academic texts

Information × Registration Number 0221U106400, 0115U006640 , R & D reports Title Experimental and clinical analysis of mechanisms of paroxysmal state in conditions of certain brain structures hyperactivation popup.stage_title Head Vastynov Ruslan S., Доктор медичних наук Registration Date 02-12-2021 Organization Odessa National Medical University popup.description2 The object of study - adult (6 months) white rats of the Vistar line weighing from 180 to 220 g. The aim of the work is to study the neuropathophysiological mechanisms of temporal lobe epileptic activity to optimize the methods of pathogenetic correction and prevention of temporal lobe epilepsy. Research methods and equipment: pathophysiological, electrophysiological and statistical. Stereotactic device SEZH-3, ADC (National Instruments, USA). It is shown that rats after intraperitoneal administration of pilocarpine (380 mg / kg) develop a complex of behavioral and electrographic disorders characteristic of status epilepticus, which is characterized by the development of spontaneous delayed seizures.The results and their novelty: based on research, new data on the role of cholinergic mechanisms in the occurrence and maintenance of chronic epilepsy of the brain, which deepen the understanding of the neuropathophysiological mechanisms of chronic epileptic activity reproduced under pilocuropyne-sylpine form. The analysis revealed a direct dependence of the frequency of spontaneous seizures in rats on the duration of acute pilocarpins - caused by seizures. It is proved that the initiation of EEG activity in the brain of rats by frontal cortex structures during SSA indicates the need for further study of the mechanisms of involvement of these formations in the mediation of chronic pilocarpine-induced convulsive syndrome, as well as the complexity, ambiguity of interpretation and systemic changes rats in the delayed period of pilocarpine EC. Diazepam, phenobarbital and valproic acid have been shown for the first time to have an antiepileptic effect on pilocarpine-induced spontaneous seizures. Diphenylhydantoin and carbamazepine do not affect the development of delayed spontaneous seizures induced by pilocarpine. It is planned to develop new therapeutic approaches that increase the effectiveness of treatment and prevention of temporal lobe epileptic activity. Product Description popup.authors Vastyanov Rooslan S Kirchev Vladyslav V M’yastkivs’ka Ivanna V Ostapenko Ihor O Savitskyi Ivan V Sadovyi Oleksandr S Sarakhan Vasyl M Stoyanov Oleksandr M popup.nrat_date 2021-12-02 Close