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Information × Registration Number 0221U106544, 0119U100232 , R & D reports Title New heterocyclic cationic surface active substances with antiseptic and antibacterial activity popup.stage_title Head Fizer Maksym M., Registration Date 14-12-2021 Organization Uzhhorod National University State Higher Educational Institution popup.description2 Cationic surfactants based on condensed cycles of 1,2,4-triazole, thienopyrimidine, pyrazolopyrimidine, thiazole, and quinazoline were synthesized for the first time. Revealed that substantial can improve the selectivity and yield triazole of fluorinated substituents when adding a calculated amount of acid anhydride trifluoroacetic acid to a solution of thiosemicarbazide in trifluoroacetic acid, allowing the first to receive appropriate fluoroalkyl-containing derivatives of 1,2,4-triazole-3-thione. Docking studies have shown that a number of the obtained compounds have a high affinity for the cell membrane, and quantitative microbiological studies for different strains of pathogens have shown that the synthesized compounds have antibacterial activity at the level of commercial drugs. Thus, the obtained new compounds can be used as bactericidal drugs.  Product Description popup.authors Golovko-Kamoshenkova Oksana Mykolaivna Devinyak Oleg Teodoziiovych Korol Nataliia I. Kut Mykola M. Pantyo Valeriy V Fizer Maksym Mykhailovych Fizer Oksana I. popup.nrat_date 2021-12-14 Close