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Information × Registration Number 0221U106655, 0119U100024 , R & D reports Title Assessment of the clinical and prognostic value of lipid metabolism disorders and humoral-cellular immunity in the early periods of acute coronary syndrome and development of method for their correction popup.stage_title Head Parkhomenko Oleksandr M., Доктор медичних наук Registration Date 16-12-2021 Organization State Institution "National Scientific Center "Institute of Cardiology named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine popup.description2 Based on the study of dynamic changes in cellular and humoral components of the immune response in patients with acute ST-segment elevation coronary syndrome (ACS), diagnostic indices for risk assessment in these patients were developed: leukocyte-platelet index (LTI) for short-term risk assesment, and modified leukocyte index (mLI) and LTI (mLTI) to determine the high risk of adverse long-term events and death in patients after ACS. 3-factor regression model of quantitative long-term risk in these patients were also developed (neutrophiles (Nph), monocytes(Mc) and percentage of platelets (Tc) size distribution (PDWc) on 7th-10th day) with AUC = 0.75 (95% CI 0.63-0.84). A treatment regimen (intravenous quercetin and trimetazidine) has been developed, which reduces the risk of nosocomial complications in patients on the background of modern basic therapy (and which should be used in patients with LTI values> 150 Units, especially in smokers and the elderly). LTI, Units = (Nph-Mc) / Lph) * 10 + PDWc + P-LCR, where: Lph - lymphocyte count, P_LCR - percentage of Tc> 12fl. mLI, Units = Nph * 4 + Mc + absolute values ​​(2,025 – Lph) * 14 + Nph(%) + Mc(%)*5+Lph(%) * 0.05 + Nph(3rd day) -Mc(1st day) * 8, where all indicators (except those specified in separate terms) are performed on the 7th-10th day of the ACS. mLTI, Units = mLI(Units) + PDWc(7th-10th day) * 2 + P_LCR (7th-10th day) * 0.4 mLI (AUC = 0.72)> 140 Units (sensitivity 65%, specificity 82%) or mLTI (AUC = 0.78)> 242 Units (sensitivity 61%, specificity 96%) indicate a high risk of any long-term cardiovascular complications, while mLI (AUC = 0.90)> 159 Units (sensitivity 89%, specificity 88%) or mLTI (AUC = 0.92)> 245 Units (sensitivity 100%, specificity 80%) - about the increased risk of long-term cardiac death in patients after ACS. Product Description popup.authors Irkin Oleg I. Biliy Dmitro O. Gavrilenko Tetiana I. Dovhan Olena V. Kozlovsky Viktor I. Lutay Yaroslav M. Pidhaina Olena A. Ponomariova Galina V. Rizhkova Natalija O. Skarzhevskiy Oleksandr A. Sokolov Maksim Yu. Stepura Anton O. Talajeva Tetiana V. Tretiak Irina V. Shumakov Oleksandr V. popup.nrat_date 2021-12-16 Close