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Information × Registration Number 0221U106858, 0120U101972 , R & D reports Title Composite nerve conduits on the basis of polymer nanofibrils and electro-conducting materials for treatment of critical neuronal injuries popup.stage_title Head Kyrylenko Sergiy D., Кандидат біологічних наук Registration Date 21-12-2021 Organization Sumy State University popup.description2  The application of nanotechnology in the development of biomaterials is currently of potential interest for medical applications. Among the polymers for this purpose, chitosan (Ch) is one of the most promising due to its biocompatibility, biodegradation and antibacterial properties. Electrospinning is an economical and well-reproducible procedure for the production of polymer nanofiber membranes. However, the electrospinning of chitosan nanofibers has some problems in obtaining homogeneous fibers and preventing their damage. To overcome some of these difficulties, current research focuses on the fabrication of chitosan nanofiber membrane by electrospinning and neutralization of 1M sodium hydroxide (NaOH), evaluation of antibacterial activity and cytotoxicity of treated chitosan nanofibers depending on different concentrations of Ag. This study aimed to develop a new Ch-AgNPs membrane using the trifluoroacetic acid / dichloromethane (TFA / DCM) co-solvent system and to assess the antibacterial potential depending on the concentration of AgNPs used. As a result of the work it was proved that the obtained Ch-based membranes with AgNPs are a promising material for tissue engineering with appropriate biocompatibility and high antimicrobial capacity after neutralization with alkali, have a suitable degradation regime, and can be used in bioengineering and medicine Product Description popup.authors Bezkorovaina Nadiia I Viter Roman V. Kazban Viktoriia S Kyrylenko Sergiy D. Korniienko Viktoriya V. Roshchupkin Anton Yanovska Hanna O. popup.nrat_date 2021-12-21 Close