Search academic texts

Information × Registration Number 0221U106944, 0120U103320 , R & D reports Title Identification of the components of signalling pathways as markers for the prediction of the invasiveness of breast cancer tumours popup.stage_title Head Rynditch Alla V., Доктор біологічних наук Registration Date 22-12-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 During the current research was created DNA construction pSUPER.retro.puro/sh-p60S6K1 for siRNA-induced selective suppression of p60 expression of the S6K1 isoform and the construction pcDNA 3.1 / p70 S6K1 and pcDNA 3.1 / p60 S6K1 to obtain model cell lines with p and p70 isoforms S6K1. We have shown that overexpression of TKS4b isoform or actin-binding protein CR16 is accompanied by increased proliferative potential and increased migration of line 293 cells. N-WASP actin and ITSN2 endocytic protein. It was found that the phosphorylation of TKS4b may depend on stimulation by phorbol ether, which activates signaling pathways that induce the formation of invadopods. It has also been shown that SAM68 RNA-binding protein can interact with the actin cytoskeleton rearrangement regulator CTTN and amphiphisins (AMPH1 and BIN1), and TKS4 and WIP proteins form complexes with proteins involved in clathrin-mediated endocytosis - AMPH1.   Product Description popup.authors Garifulin Oleg Minirovich Gryaznova Tetyana Anatoliіvna Dudchenko Taras M. Kropyvko Sergiy Viktorovych Krupska Iryna V Pankyvskyi Sergii Volodymyrovych Savins'ka Liliya Oleksiivna Filonenko Valeriy Viktorovych Iungin Olga S. popup.nrat_date 2021-12-22 Close