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Information × Registration Number 0221U107280, 0118U003121 , R & D reports Title Development of methods for asymmetric synthesis of compounds with potential biological activity popup.stage_title Head Kolodiazhnyi Oleg I., Доктор хімічних наук Registration Date 30-12-2021 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Studies devoted to the development of methods for deracemisation of organic and organometallic compounds have been performed. Enzymatic synthesis of 1,2-aminocyclopentanols and 1,2-diaminocyclopentans, which are important pharmacophore groups, was performed. 2 (P) -Electrophilic substitution in chiral trivalent or pentavalent phosphorus compounds was investigated by stereochemistry. It was found that the reaction proceeds at the center of the highest electron density near the phosphorus atom on the front side while maintaining the absolute configuration. Enzymatic catalysis methods were used to obtain chiral synthetic blocks for the production of crixivane, including derivatives of 1,2-haloindenols, 1,5-haloindenols, and 1,4-dihydroxyindenols. Product Description popup.authors Grishkun Evgeny V. Kibiryev Volodymyr K. Kolodiazhna Anastasiia O. Kolodiazhna Olga O. Osadchuk Tetiana V. Prisyajnyuk Dmitry V. Slastennikova Alyona O. Shejko Sergij Yu. popup.nrat_date 2022-03-09 Close