Search academic texts

Information × Registration Number 0222U000011, 0121U113543 , R & D reports Title Immunological and biochemical comparison of the resistance of invasive and native bivalve mollusks to environmental challengers popup.stage_title Head Stoliar Oksana B., д.б.н. Registration Date 01-01-2022 Organization Ternopil National Pedagogical University named after Volodymyr Hnatyuk popup.description2 Significant differences between populations of the same species in terms of oxidative stress and the ability to accumulate zinc in tissues and metal-binding proteins metallothioneins have been proved. The tissue of zebra mussels samples was prepared for study by a French partner. According to the eco-exposome concept regarding the dependence of immunoreactivity on the functional activity of zinc in cells, the sensitivity of zinc metabolism to a model of the inflammatory process in vertebrates was elucidated. The presence of metallothioneins and their functional activity associated with zinc accumulation in synovial tissue in an experimental model of acute gonarthritis have been proved. In an ex vivo experiment, evidence was obtained for the effect of zinc on the apoptosis enzyme caspase-3 and the participation of glutathione in the reaction to the effect of the roundup prooxidant (glyphosate) for the express analysis of the acute toxic effect of drugs. An ex vivo model is recommended for assessing the acute toxicity of xenobiotics. Product Description popup.authors Baranovskyi Vitaliy S. Martynyuk Victoriya V. Matskiv Tetyana R. Мatsuk Oksana B. Symchak Ruslan V. Tulaydan Galuna M. Khoma Vira V. popup.nrat_date 2022-03-09 Close