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Information × Registration Number 0222U000055, 0117U000021 , R & D reports Title Obtaining of biologically active compounds and monomers based on the principles of supramolecular catalysis and "green" chemistry popup.stage_title Head Popov Anatolii , Доктор хімічних наук Registration Date 02-01-2022 Organization L.M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry of the NAS of Ukraine popup.description2  The object of study - 2,5 - disubstituted furans and their oxidation products, in particular, 2,5-furandicarboxylic acid. The aim of the work is to determine the theoretical foundations of the technology of directed synthesis of 2,5-furandicarboxylic acid by aerobic oxidation of 2,5-disubstituted furans catalyzed by N-hydroxyimide radicals. Research methods - NMR, IR spectroscopy, kinetic measurements, chromatography, UV spectroscopy A screening series of compounds that can be formed during the processing of sugar-containing plant biomass and act as starting compounds in the development of technology for the production of 2,5-furanedicarboxylic acid, to study the catalytic activity of homogeneous catalysts. Optimized and improved methods for obtaining a number of 2.5-disubstituted furans, which significantly increased the yields of the target compounds and improve their quality. The method of synthesis of double simple ether of 5-hydroxymethylfurfural, which is characterized by increased storage stability, has been developed and improved. The course of the oxidation reaction of substituted furans by molecular oxygen in a wide temperature range in the presence of the catalytic system N-hydroxyphthalimide - transition metal ions (Co, Mn, V) was studied and the main oxidation products were determined. To establish the elementary stages of the mechanism, the elementary reaction of separation of the hydrogen atom by N-oxyl radicals formed from nitroxyl radicals by oxidation with iodobenzene diacetate in acetonitrile was investigated from CH bonds on a number of furan derivatives by UV spectroscopy and the change in reactivity in a number of substituted N-hydroxyimides when interacting with 2,5-disubstituted furans was determined. Product Description popup.authors Efimova Irina V. Anischenko Vісtor M. Anishchenko Hanna V. Dykun Oleksiy M. Kompanets Mikhaylо О. Korzhenevska Nadiia Н. Ostapiuk Svitlana M. Redko Andriy M. Rybachenko Volodymyr I. Tamarkina Yuliya V. popup.nrat_date 2022-03-09 Close