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Information × Registration Number 0222U000128, 0120U100309 , R & D reports Title Directed synthesis of novel nitrogen- and oxygencontaining heterocyclic compounds as low molecular weight bioregulators. popup.stage_title Head Brovarets Volodymyr S., Доктор хімічних наук Registration Date 03-01-2022 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 The interaction of 2-chloro-N-(2,2-dichloro-1-cyanovinyl)acetamide with dimethylamine was studied. This gives 5-(dimethylamino)-2-[(dimethylamino)methyl]-1,3-oxazole-4-carbonitrile, which is regioselectively alkylated with iodomethane on the aliphatic dimethylamino group. The interaction of existing 1-acylamino-2,2-dichlorotenyl(triphenyl)phosphonium chlorides with alkanolamines having a primary amino group has been shown to lead to the formation of 4-oxazolylphosphonium salts having hydroxyalkylamine residues in the fifth oxo cycle. A convenient method for new phosphorylated peptidomimetics containing C-terminal ω-haloalkyl and ω-thiocyanoethyl synthesis has been developed in the interaction of 2-aryl-5-(hydroxyalkylamino)-1,3-oxazol-4-yl)phosphonates with hydrogen chloride and hydrogen thiocyanate in anhydrous medium. A new high-yield heterocyclic system of 5H-imidazo[1,2-e][1,3,5]triazepine was obtained. The interaction of the starting 1-aryl-2-azatetrachloro-1,3-butadienes with 2-(aminomethyl)imidazole occurs by regioselective annealing to the imidazole nucleus of the triazepine cycle. Product Description popup.authors Ivanova Irina V. Abdurakhmanova Esma R. Biletska Іryna M. Veligina Yevheniia S. Vydzhak Roman M. Herasymov Yehor S. Golovchenko Оleksandr V. Didiv Nataliya D. Demydchuk Bogdan A. Zhirnov Viktor V. Zyabrev Volodymyr S. Kachaeva Maryna V. Kachkovskyi Oleksiy D. Кlyuchko Svitlana V. Kozachenko Olexandr P. Kondratyuk Kostyantyn M. Mityukhin Оleg P. Merzhievskiy Danylo O. Moskvina Viktoria S. Mrug Galyna P. Pilyo Stepan G. Panchyshyn Svitlana Ya. Polovko Тetiana A. Porhun Svitlana V. Potikha Lyudmyla M. Prokopenko Volodumir M. Prostota Yaroslav O Rentsevych Тetiana L. Severin Oleksandr O. Synenko Vitaliy O. Slyvchuk Serhiy R. Solomyanyi Roman M. Frasinyuk Mykhaylo S Tsygankova Viktoriia А. Charochkina Larysa L. Chumachenko Svitlana A. Shablykin Оleg V. Shablykina Olga V. popup.nrat_date 2022-03-09 Close