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Information × Registration Number 0222U000131, 0121U110488 , R & D reports Title Enzymatic deracemisation and synthesis of chiral potentially bioactive compounds popup.stage_title Head Kolodiazhna Anastasiia O., д.х.н. Registration Date 03-01-2022 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 According to the results of scientific work, research was conducted on the development of reagents for asymmetric synthesis and kinetic enzymatic resolution of racemates and their use to obtain new biologically active compounds. With the help of enzymatic methods of resolution of racemic indenols and their subsequent functionalization, derivatives of pharmacophore compounds (indenols, dehydroindenols, dehydroindendiols,) of high degree of optical purity were obtained. Biocatalytic purification of halocycloalkanol derivatives, fluoroaminoalkanes, aminocyclopentanols, etc. was carried out, and new optically active substances were obtained. The influence of the Koshland effect with the adaptation of the active center of the enzyme to the shape of the substrate on the course of enzymatic separation reactions was established for the first time. A simple method for determining the absolute configuration of indenol derivatives and functionalized vicinal cycloalkanols using chiral liquid chromatography was proposed. Biological researches in Silico of synthesized compounds using molecular docking have been performed. The dependence of the inhibitory activity of compound enantiomers on the absolute configuration is shown on the example of a number of enzymes Product Description popup.authors Kolodiazhna Olga O. Prisyajnyuk Dmitry V. Tatarchuk Alʹona V. popup.nrat_date 2022-03-09 Close