Search academic texts

Information × Registration Number 0222U000135, 0117U000096 , R & D reports Title Synthesis of heterocyclic nitrogen and organo-phosphorus compounds and research of their biological activity. popup.stage_title Head Vovk Andrii I., д.х.н. Registration Date 03-01-2022 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 New phosphonopeptidomimetics were synthesized and their effect on the functional state of the rat heart was studied for the first time. A series of new 1,3-oxazole derivatives was synthesized, their antiviral activity against human papilloma virus in vitro with IC50 in micromolar concentrations was studied. New derivatives of 5-amino-1,3-oxazole-4-carbonitrile have been synthesized and their effect on a number of cancer cell lines has been studied, and the relationship between the structure and activity of these compounds has been studied. Preparative methods for the synthesis of pyrido[2,3-d]pyrimidin-7-one derivatives containing primary and secondary amine residues at position 4 of the heterocyclic system have been developed. Stereoselective methods for the synthesis of α- and ɤ-derivatives of tetradecapentaenoic acid have been developed, which were previously isolated from natural raw materials and are inhibitors of cell proliferation and activators of apoptosis. Asymmetric synthesis of (RS)- and (RR)-S-alkyl-substituted cysteine sulfoxides was performed. New approaches to the construction of cholinesterase inhibitors have been developed, and new O-substituted N-benzyl structural analogs of vitamin B1 have been synthesized and studied, which can effectively and selectively block the activity of acetylcholinesterase and butyrylcholinesterase, which are targets for Alzheimer's disease. The directions of construction of potentially bioactive nitro derivatives of aurons as new antioxidants and xanthine oxidase inhibitors was substantiated. The properties of new derivatives of rhodanine as inhibitors of glutathione-S-transferase and protein tyrosine phosphatases were established. The biological activity of a number of nitrogenous heterocycles on plant model systems was analyzed and this activity was compared with natural phytohormones cytokinins. Product Description popup.authors Ivanova Irina V. Abdurakhmanova Esma R. Biletska Іryna M. Biletsky Igor І. Brovarets Volodymyr S. Buldenko Vladyslav M. Bukhonska Yaroslava К. Veligina Yevheniia S. Verves Evgeniy V. Verevka Oleg S. Vydzhak Roman M. Gayevsky Anatoly P. Herasymov Yehor S. Golovchenko Оleksandr V. Grishkun Evgeny V. Goodima Andrew О. Hurenko Artem O. Hushcha Tatiana О. Didiv Nataliya D. Demydchuk Bogdan A. Derevyanchuk Michael V. Zhirnov Viktor V. Zinchenko Hanna M. Zyabrev Volodymyr S. Kibiryev Volodymyr K. Karpets Leyla-Anastasiya М. Kachaeva Maryna V. Kachkovskyi Oleksiy D. Klyuchko Svitlana S. Kobzar Oleksandr L. Kozachenko Olexandr P. Kolesnikov Yaroslav S. Kolodiazhna Anastasiia O. Kolodiazhna Olga O. Kolodiazhnyi Oleg I. Kondratyuk Kostyantyn M. Кravets Volodymyr S. Kretynin Serhiy V. Kukuyev Maksym О. Kucher Oleksandr V. Mityukhin Оleg P. Mischenko Iryna M. Melnyk Andrii К. Merzhievskiy Danylo O. Mykula Mariya S. Moskvina Viktoria S. Mrug Galyna P. Muzychka Lyubov V. Muzychka Oxana V. Nikolayevska Valentyna І. Osadchuk Tetiana V. Ocheretnyuk Alla D. Pilyo Stepan G. Panchyshyn Svitlana Ya. Plokhovska Svitlana H. Pokotylo Igor V. Polovko Тetiana A. Popova Antonina V. Porhun Svitlana V. Prisyajnyuk Dmitry V. Prokopenko Volodumir M. Prostota Yaroslav O Rentsevych Тetiana L. Synenko Vitaliy O. Slastennikova Alyona O. Slyvchuk Serhiy R. Smoliy Oleg B. Solomyanyi Roman M. Sukhoveev Olexandr V. Tanchuk Vsevolod Yu. Tatarchuk Alʹona V. Trush Viacheslav V. Turov Кostyantyn V. Frasinyuk Mykhaylo S Charochkina Larysa L. Chumachenko Svitlana A. Shablykin Оleg V. Shablykina Olga V. Shejko Sergij Yu. Shulga Yuriy V. Iakovenko Іgor N. Yakovenko Oksana М. Yaremchuk Iryna О. popup.nrat_date 2022-03-09 Close