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Information × Registration Number 0222U000450, 0117U001084 , R & D reports Title Оptimisation of prognosis and treatment patients with locally-advanced, metastatic and reccurent cancer of digestive tract, lungs, reproductive system, breast: influence of surgery in MDT popup.stage_title Head Fetsych Taras, д.мед.н. Registration Date 10-01-2022 Organization Danylo Halytsky Lviv National Medical University popup.description2  The pathogenetic role of certain cellular and molecular factors of the tumor microenvironment in the progression of RGD and OC has been studied, their prognostic informativeness has been determined, and therapeutic measures have been developed to neutralize their negative effect. In particular, the levels of expression of polyfunctional cytokines CNP and TGF-β, expression of laminin, CD44 and its isoforms, the number and functional activity of tumor-associated macrophages, the degree of microvascularization at the stage of local tumor growth and its distribution in patients with RGD Indicators of unfavorable prognosis and aggressive clinical course of RGD have been shown to be high macrophage infiltration, increased expression of CNS in cancer tissue, high tumor microvascularization, high expression of CD44v5 isoform CD44, decreased laminin expression and TGF-β-associated metastasis to regional lymph nodes and worse survival. A comparative analysis of peritoneal cancer indices determined by CT and intraoperative revision, which showed a statistically significant difference between them (x̄KT = 3.71, x̄OP = 10.05, p <0.0001) . This indicates a tendency to underestimate the peritoneal cancer index, calculated according to CT. The use of single-cut CT with contrast enhancement in patients with colorectal cancer has demonstrated low diagnostic value of this method in the detection of peritoneal carcinomatosis. Along with the high specificity of single-slice CT has a low sensitivity for the detection of peritoneal metastases, especially in the early stages of peritoneal carcinomatosis. The study of the effectiveness of multislice CT with the possibility of making thin sections will be continued in the future. Thus, the diagnosis of peritoneal carcinomatosis in patients with OC using CT has certain limitations. However, due to its availability, CT remains the most commonly used method for staging the disease. Despite the possible deviations in the preoperative assessment Product Description popup.authors Bilynskyi Borys Tarasovych Volodko Nataliya Volodumyrivna Hipp Ihor Hryhorovych Dutchak Uliana Myroslavivna Kovalskyi Vasyl Volodymyrovych Lukavetskyi Nazar Oleksiiovych Mazur Yuliia Yuriyivna Mryglotskyi Marian Mykhailovych Oliynuk Yuriy Yuriyovych Prystash Yuriy Yaroslavovych Revura Andriy Petrovych Savran Volodymyr Romanovych Slipetskyi Roman Rostyslavovych Sternyuk Yuriy Marianovych Ferneza Severyn Romanovych Fetsych Markiyan Tarasovych Yakubets Olha Igorivna Yarema Roman Romanovych popup.nrat_date 2022-03-09 Close