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Information × Registration Number 0222U000603, 0119U100563 , R & D reports Title Determination of the neurophysiological basis of cerebro-ophthalmological effects of small doses of irradiation popup.stage_title Head Loganovsky Kostiantyn M., Доктор медичних наукFedirko Pavlo A., Доктор медичних наук Registration Date 13-01-2022 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  109 irradiated persons were examined (in adulthood (n=57) and prenatally (n=52) and 104 persons of comparison groups (participants of ATO / OOS (n=51)) and normative control (n=53). Research methods: neuropsychiatric, ophthalmological, psychodiagnostic, neuropsychological, neurophysiological, statistical. Radiation-associated cerebroophthalmic pathology is characterized by high neuropsychiatric and ophthalmic comorbidity, which increases in proportion to the radiation dose, and is mainly represented by chronic vascular-degenerative diseases of the brain and retinal detachment, which are characterized by radiation dose (in the distant period of radiation in adulthood) and disorders of the autonomic nervous system, certain signs of demyelination, non-psychotic organic mental disorders, neurotic, stress-related and somatoform disorders, as well as vascular and dystrophic processes in the retina (after exposure in utero). Characteristic neurocognitive deficits after irradiation in different radiological scenarios indicate the lateralization of the lesion to the left hemisphere of the brain. Neurophysiological basis - damage to the cortico-limbic system of the brain and the central mechanisms of afferent visual analyzer. Biomarkers of cerebral lesions have been identified for the first time using BDNF. The concept of radiation-associated cerebroophthalmological effects is defined. A new non-invasive neurophysiological technology for determining radiation-associated cerebroophthalmological effects has been proposed. Innovative diagnostic criteria of this pathology are developed, on the basis of modern neuropsychological and neurophysiological technologies (mapping of kEEG, VEPCP, cognitive VEP, BDNF). Product Description popup.authors Antypchuk Kateryna Yu. Babenko Tetyana F. Dorichevska Raisa Yu. Kreynis Georgiy Yu. Kuts Kostiantyn V. Loganovska Tetiana K. Masiuk Sergii Volodymyrovych Perchuk Iryna V. Pleskach Oksana Ya popup.nrat_date 2022-03-09 Close