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Information × Registration Number 0222U000665, 0120U103068 , R & D reports Title The influence of the newest modulators of GABA-ergic system at disorders of excitability of a brain of mammals popup.stage_title Head Kryshtal Oleg O., Доктор біологічних наук Registration Date 14-01-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  GABA A-type receptor-channel complexes are considered as the main and promising target in the development of anticonvulsant drugs for the treatment of epileptic conditions. The search for new compounds that are able to regulate the activity of GABA receptors in the absence of side effects of drugs based on them is of great relevance to medicine. The project screened the activity of synthesized compounds (7 molecules), which are a modification of the compounds of the previous series, in relation to GABA A-type receptor-channel complexes of Purkinje neurons. Compounds Z 10365-8095 and Z 17215-6491 were found to be able to enhance the activity of GABA receptors, and compound Z 11178-2830 has a moderate inhibitory effect on GABA A-type receptor-channel complexes. In the model of generalized epilepsy, changes in the work of inhibitory systems under the influence of synthesized molecules were studied. Compound Z 10365-8095 was found to reduce the frequency of electrographic discharges in 4AP and the cabinet model of epilepsy. Further research and possible optimization of the structure of molecules (Z 10365-8095) may be successful in creating a prototype of a new class of modulators of GABA A-type receptors to create anticonvulsant drugs. Product Description popup.authors Iegorova Olena V Kulyk Vyacheslav B Maximyuk Olexandr P Khmyz Volodymyr V. popup.nrat_date 2022-03-09 Close