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Information × Registration Number 0222U000742, 0116U005242 , R & D reports Title Apoptogenic and immunosuppressive potential of bacteria and fungi popup.stage_title Head Гайдаш Ігор Славович, Registration Date 18-01-2022 Organization The State Institution "LUGANSK STATE MEDICAL UNIVERSITY" popup.description2  Abstract Report 75 P., 1 book, 571 literature sources Relevance of the topic. Endotoxins of pathogenic bacteria cause apoptosis and functional disorder in immunocompetent cells due to their endotoxins, which negatively affect the state of lipid peroxidation, the system of cyclic and adenyl nucleotides. Purpose of the study. To study the immunosuppressive and apoptogenic potential of lipopolysaccharides (LPs) of shigella bacteria. Materials and methods of research. Cultures of human blood cells (neutrophils, monocytes, T-lymphocytes). Research methods: microbiological, immunological, biochemical, statistical. Research results. Direct contact of LPs of shigella bacteria with neutrophils, monocytes and T-lymphocytes of human blood increases the number of cells with markers of apoptosis. Conclusions. Direct contact of LPs of shigella bacteria with neutrophils, monocytes, and T-lymphocytes in a dose-dependent manner stimulates their apoptosis. Key words: lipopolysaccharide, Shigella, neutrophils, monocytes, T-lymphocytes, apoptosis. Product Description popup.authors Bondar Oleksiy Oleksiyovich Burtsev Oleksiy Volodimirivich Haydash Iryna Anatolyivna Haydash Dmitro Ihorovich Haydash Olena Ihorivna Hlazkova Natalia Oleksiivna Shabelnik Oleg Ivanovich Yanchevsky Oleksandr Valeriyovich popup.nrat_date 2022-03-09 Close