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Information × Registration Number 0222U000810, 0118U005185 , R & D reports Title Development of 2D-materials and "smart" sensors for medical and biological purposes on their basis. Section 3. 2D-materials based on BN and WS2 as potential antitumor and antimetastatic agents popup.stage_title Head Solianyk Halyna I., Доктор фізико-математичних наук Registration Date 18-01-2022 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 It was conducted the primary screening of the cytotoxic/cytostatic action of 2D-nanomaterials based on WS2 and MoS2 against tumor cells. It was established that 2D-nanomaterials based on WS2 and MoS2 in concentrations studied demonstrated a moderate concentration-dependent cytotoxic activity against LLC and LLC/R9 cells, which was potentiated in the case of increase of long-term incubation. IC50 for WS2 for LLC cells was 201,2+15,6 mkg/ml for 24 h incubation and 99,9+2,4 mkg/ml for 48 h incubation. IC50 for WS2 for LLC/R9 cells was 158,1+6,6 mkg/ml for 24 h incubation and 118,4+6,5 mkg/ml for 48 h incubation. Cytotoxicity of nanoparticles based on MoS2 also raised with increasing long-term incubation. Instead, IC50 for MoS2 for LLC cells was 296,7+28,1 mkg/ml for 24 h incubation and 59,5+6,3 mkg/ml for 48 h incubation. IC50 for MoS2 for LLC/R9 cells was 191,6+9,4 mkg/ml for 24 h incubation and 64,8+7,4 mkg/ml for 48 h incubation. Our results show that commercial 2D-nanomaterials (Sigma-Aldrich) based on WS2 and MoS2 demonstrate a moderate cytotoxic/cytostatic action against cells of two Lewis lung carcinoma. Such cytotoxic/cytostatic action of commercial 2D-nanomaterials was dramatically elevated by increasing long-term incubation. Product Description popup.authors Kolesnik Denis L. Pyaskovska Olga M. popup.nrat_date 2022-03-09 Close