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Information × Registration Number 0222U000922, 0119U100770 , R & D reports Title Determination of the effectiveness of plasma electrooxidation for modification of biodegradable alloys for orthopedics popup.stage_title Head Oleshko Oleksandr M., Кандидат медичних наук Registration Date 21-01-2022 Organization Sumy State University popup.description2  To achieve this goal, the following tasks were identified: 1. Creation of working solutions and selection of modes (voltage, current, time) of plasma electrooxidation to create oxide films on the surface of magnesium alloys. 2. Formation of oxide film on the surface of magnesium alloys with the addition of different concentrations and shapes of nanoparticles of silver and zinc oxide. 3. Determination of physicochemical, corrosion, structural and optical characteristics of the surface of implants obtained by different methods. 4. Determination of the degree of adhesion, proliferation and metabolism of cells during cultivation on implants with a functionalized surface. 5. Generalization of research results in terms of the possibility of creating biodegradable orthopedic implants. Studies of the quality of the modified surface of magnesium alloys, in particular the dynamics of resorption of alloys, thickness and chemical composition, as well as features of film morphology, its mechanical properties, which allowed to determine the structure and elemental composition of the surface. Namely, the formation of an oxide layer with a phosphate and sulfate component. Assessment of cytotoxicity and biocompatibility with cell lines, in particular on commercially available U2OS (osteoblastic differon cells) cell lines. Study of biological response due to the characteristics of the processes of adhesion and proliferation of cells, the presence of matrix mineralization, as well as metabolic processes (collagen synthesis, alkaline phosphatase, formation of crystalline hydroxyapatite) Product Description popup.authors Hapchenko Andrii V. Husak Yevheniia V. Deineka Volodimyr M. Dryhval Bohdan O. Dudko Yuliia S. Lyndin Mykola S. Myronov Petro F. Oleshko Oleksandr M. Savchenko Anton V. Yusupova Aziza F. popup.nrat_date 2022-03-09 Close