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Information × Registration Number 0222U001027, 0120U104127 , R & D reports Title Neuroprotective action of vitamin D3 in glucocorticoid-induced neurotoxicity popup.stage_title Head Shimanskiy Igor O., Кандидат біологічних наук Registration Date 23-01-2022 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 The increase in the expression level of the p65 subunit of the nuclear factor κB (NF-κB) as well as its specific phosphorylation at various amino acid residues demonstrated the possibility of involving the canonical NF-κB signaling pathway in the mechanism of glucocorticoid-induced neurotoxicity. Determination of molecular markers of apoptosis and histochemical detection of apoptotic changes using the TUNEL method allowed establishing the intensification of the process of programmed cell death in the brain of rats with prolonged exposure to prednisolone. A decrease in the number of neurons in the hippocampus has been shown. Increased cell death was accompanied by inhibition of the proliferation process in various structural areas of the brain, mainly due to microglia. Therapeutic administration of vitamin D3 partially corrected long-term prednisolone-induced changes in rat brain, indicating the possibility of VDR-mediated modulation of NF-κB-associated processes in the mechanism of antiapoptotic and neuroprotective effects of vitamin D3.  Product Description popup.authors Isayev Dmytro Sergiyovych Velykyi Mykola M. Lisakovska Olha O. Labudzynskyi Dmytro O. Khomenko Anna Victororivna popup.nrat_date 2022-03-09 Close