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Information × Registration Number 0222U001056, 0120U104883 , R & D reports Title Enzymes of post-translational modifications of microtubule proteins as targets for inhibition of the excitability of primary nociceptive neurons popup.stage_title Head Karpov Pavlo A., Доктор біологічних наук Registration Date 23-01-2022 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2 Within the framework of the stage, promising interaction sites, contact interfaces of target proteins and tubule microtubules, sites influencing this interaction were identified. Priority sites included the binding site of TRPV resiniferatoxin / capsazepine and nicotinamide 35 in the case of P2X. For TRPV3 and 4, RTX, PIP2 and APB sites were identified. Priority molecular targets, optimal protocol, conditions and control of molecular docking are determined. A screening protocol based on cross-validation of molecular docking results and pharmacophore analysis has been developed.  Product Description popup.authors Karpov Pavlo A. Novozhylov Dmytro O. Rabokon Anastasiya M. Samofalova Dariya O. Stikhilyas Mariya M. popup.nrat_date 2022-03-09 Close