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Information × Registration Number 0222U001093, 0119U100152 , R & D reports Title To study the clinical and pathogenetic, neurobiological and biochemical mechanisms of neuroplasticity as the basis of adaptation in demyelinating and degenerative pathologies popup.stage_title Head Voloshyna Nataliia P., Доктор медичних наук Registration Date 24-01-2022 Organization State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine" popup.description2 204 p., 37 tab., 50 fig., 5 append., 283 sources. NEUROPLASTICITY, DEMYELINATING AND DEGENERATIVE PATHOLOGY, MULTIPLE SCLEROSIS, WILSON’S DISEASE, COGNITIVE IMPAIRMENTS, PHYSICAL REHABILITATION, TMS. Object: patients with multiple sclerosis (MS), patients with hepatocerebral degeneration (Wilson’s disease (WD)). Aim: to detect of morphological-structural (MSt), neurofunctional, and biochemical signs of adaptive and maladaptive brain reorganization in response to demyelinating and degenerative brain damages, to define effective methods of modulation of neuroplasticity (NP). A comparative analysis of MSt brain changes (MStBChs) has demonstrated, that in MS, volume of damage does not always coincide with levels of neurological deficit manifestation, cognitive impairments, rate and completeness of impaired function recovery. In WD a neurological deficit severity mostly coincides with MStBChs level. Differences in ratio of clinical and cognitive manifestations of the disease progress, as reflection of type of adaptivity of NP changes in MS, were stipulated by different tactics of neuronal networks reorganization at rest. The “only that is necessary” tactics was the most adaptive; efficacy of involvement of neocortex and subcortical structures on “all that possible” principle was limited by time and type of loading; the tactics of a selective enhancing of certain neuronal networks/links to decrease “value” of adaptation was effective only for appropriate functional systems. NP changes in WD were similar to ageing ones; when a critical volume of degeneration was reached, a decreasing of a potential reserve of neuroplasticity made an effective compensation of cognitive and sensomotor functions impossible. A decreasing of clinical manifestations and positive dynamics of the disease progress markers in applying of TMS for MS and a complex of physical rehabilitation for MS and WD along with a pharmacotherapy, has showed an efficacy of usage of these methods to manage NP. Product Description popup.authors Bohdanova Taisiia Volodymyrivna Богданова Ірина В'ячеславівна Vasylovskyy Vitaliy Vadymovych Voloshyn-Haponov Ivan Kostiantynovych Gaponov Petro Kostiantynovych Kutikov Damir Oleksandrovych Kutikov Oleksandr Yevhenovych Nikishkova Iryna Mykolayivna Negreba Tetyana Valerianivna Pisotska Kseniia Olehivna Petrukhina Nina Dmytrivna Pogulyayeva Tetyana Mykolaiivna Prylepa Valentyna Oleksandrivna Chernenko Maksym Yevhenovych popup.nrat_date 2022-03-09 Close