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Registration Number

0222U001137, 0121U112930 , R & D reports

Title

Іntermittent hypoxia as a novel strategy for treatment/prevention of Alzheimer disease: molecular mechanisms and therapeutic implementation.

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Head

Serebrovska Zoia O., Кандидат біологічних наук

Registration Date

24-01-2022

Organization

Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine

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 Intraventricularc injection of streptozotocin increases the level of Ab1-42 in the tissues of the hippocampus and frontal cortex, increases the expression of APP, and does not affect the expression of BASE1a. Another effect is the activation of inflammatory processes in the hippocampus and frontal cortex, as evidenced by TNFa accumulation and at organism level: increasing the level of CytC in the blood, increasing the formation of NETs, and the activity of MMP2. The use of IHHT leads to a decrease in the content of Av1-42, APP and decreases expression of inflammatory markers. This effect does not NETs formation in rats. The results of a study in humans and in an experiment on NETs do not match. IHHT in humans has led to a significant reduction in the expression of long non-coding RNA HIF1a -AS, a blocker of HIF1a translation. These results suggest that the obtained effects of IHHT depends at least partialy on the transcription factor HIF1a and its targets.

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Goncharov Serhiy V.
Hryb Oksana M
Gushcha Valeria V.
Kozak Taisiya O.
Polishchuk Anna O.
Tumanovska Lesia V.
Hetsuriani Mykhaylo R.

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2022-03-09