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Information × Registration Number 0222U001138, 0121U112151 , R & D reports Title Development of new methods to increase the expression of ATP-sensitive potassium channels of cell membranes as a powerful universal system of endogenous protection popup.stage_title Head Strutynskyi Ruslan B., Доктор біологічних наук Registration Date 24-01-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 New methods have been developed to increase the expression of KATP channels, which consist of the use of pyridoxal-5-phosphate and glutathione. Electrophysiological and strain gauge experiments on isolated cardiomyocytes and vascular strips, respectively, showed a significant increase in effects through KATP channels, which may indicate an increase in their density on cell membranes. Experiments with ischemia-reperfusion of an isolated heart, the study of the opening of mPTP (mitochondrial permeability transition pore), and the determination of biochemical parameters showed an increase in cardioprotective effects in these animals. Product Description popup.authors Goshovska Julia V. Korkach Julia P. Krukoves Serhiy G. Mys Lidiya A. Okhay Iryna Y. Rovenets Roman A. Sagach Vadim F. Svarichevsky Oleg V. Strutynska Natalia A. Strutynsky Vladislav R. Fedichkina Raisa A. Sharopov Bizhan R. Shysh Anzhela M. Shuba Yaroslav М. popup.nrat_date 2022-03-09 Close