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Information × Registration Number 0222U001221, 0119U000088 , R & D reports Title Development of methods for increasing the efficiency of immune system regeneration based on transplantation of cytokine-stimulated multipotent stromal cells popup.stage_title Head Nikolskyi Ihor S, Registration Date 25-01-2022 Organization Institute of genetic and regenerative medicine National Acad.Med.Sci. of Ukraine popup.description2 It was found that as a result of exposure of cells to proinflammatory factor lipopolysaccharide (LPS) stimulates the growth kinetics of MSCs, their colonogenic potential, the ability to contact lymphocytes and antiproliferative activity in vitro. Dexamethasone has no such effect. The growth kinetics of MSCs are also significantly stimulated by incubation of cells with PRP in vitro. Under the influence of the introduction of MSCs is the abolition of cyclophosphamide mobilization, more effective with the introduction of MSCs preincubated with PRP, normalizes the level of lymphocytes. Fetal MSCs normalize the number of platelets and reticulocytes, and preincubated with PRP MSCs increase hemoglobin. MSCs preincubated with LPS stimulate the natural cytotoxicity of splenocytes. Pre-incubated with PRP MSCs stimulate the formation of antibody-producing cells and increase to a normal level the activity of delayed-type hypersensitivity, which generally indicates stimulation of the immunoregulatory action of MSCs as a result of exposure to pro-inflammatory factors.  Product Description popup.authors Demchenko Dariia Leonidivna Nikolska Valentina V Semenova Yanina-Mariya Taranukha Lyubov I popup.nrat_date 2022-03-09 Close