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Registration Number

0222U001261, 0119U101473 , R & D reports

Title

Study of hormonal and metabolic pathways of parathyroid disorders in survivors exposed to ionizing radiation as a result of the Chornobyl accident

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Head

Kaminskyi Oleksii V., Доктор медичних наук

Registration Date

26-01-2022

Organization

State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"

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 Object of the study: 170 adults affected by the Chornobyl accident and 145 of their descendants, compared to the total population (61 and 54 persons, respectively), 430 subjects the total study sample. Methods: generally accepted clinical, anthropometric (body mass, height, thigh volume, body mass index), instrumental (thyroid and parathyroid ultrasound examination), laboratory (biochemical, hormonal), statistical. Results. The pathogenetic hormonal and metabolic interrelation between endocrine disorders (hypothyroidism, obesity, insulin resistance, diabetes mellitus, metabolic syndrome and secondary hyperparathyroidism) in the Chornobyl accident survivors and parathyroid hyperplasia has been established. An increase in the incidence of parathyroid hyperplasia in the late period of the Chornobyl accident (over 30 years) was found in 39.2% of the adult survivors and 51.4% of their offspring, which is 1.8 times more (p ≤ 0.01), than in the control group. Elevated levels of parathyroid hormone was found in the Chornobyl NPP accident clean-up workers of the “iodine period” with parathyroid hyperplasia (p < 0.05). The 94% of subjects were diagnosed with vitamin D deficiency, which significantly affected the increase in the incidence of parathyroid hyperplasia, which was detected by ultrasound. A strong relationship was found between the HOMA index and the concentrations of vitamin D (r = 0.65), FT4 (r = 0.68), parathyroid hormone (r = 0.60) in children with autoimmune thyroiditis and hypothyroidism, which may indicate abnormal metabolism and endogenous synthesis of vitamin D with the development of its deficiency in most descendants of survivors. Low levels of serum vitamin D ((16.8 ± 2.04) nmol / l) were found in all groups of examined children. Approaches to early diagnosis of parathyroid disease with the use of ultrasound, which is an effective clinical diagnostic method for screening of parathyroid hyperplasia, have been improved.

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Afanasiev Dmytro Eugenovych
Kopylova Olga Vasylivna
Muravyova Iryna Mykolayivna
Chykalova Iryna Grygorivna

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2022-03-09