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Information × Registration Number 0222U001511, 0121U112551 , R & D reports Title Myogenic mechanisms of urinary bladder mechanical sensitivity in norm and type 2 diabetes. popup.stage_title Head Shuba Yaroslav М., Доктор біологічних наук Registration Date 28-01-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Investigetion have shown that: 1) in the presence of activator PIEZO1-channelsYoda1 voltage generation by DSM bands in the removed urothelium increases, and in diabetes this effect is eliminated; 2) diabetes virtually eliminated the effect of both activator (GSK 1016790A) and blocker (CH-067047) channel TRPV4 on the tension of DSM bands in response to stretching in the presence of urothelium, while in the absence of urothelium activator increased and blocker decreased stress; 3) blocking TREK-1 (KCNK2) channels with L-methionine causes an increase in stress in response to stretching, while neither the presence of urothelium nor the induction of diabetes significantly affected the magnitude of the effect. Product Description popup.authors Yelyashov Semen I. Kravchuk Danylo I. Sotkis Anna V. Stoliar Liubov A. Philipov Ihor B. Sharopov Bizhan R. Shuba Yaroslav М. popup.nrat_date 2022-03-09 Close