Search academic texts

Information × Registration Number 0222U001631, 0121U112145 , R & D reports Title Molecular design, creation, in vitro and in vivo screening of nanocomplexes of natural alkaloids with C60 fullerene to increase the effectiveness of metastatic cancer therapy. popup.stage_title Head Matyshevska Olha P., д.б.н. Registration Date 31-01-2022 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 In contrast to alkaloids in free form, their nanocomplexes with fullerene C60 were demonstrated to have higher efficacy towards suppressing the viability, motility, and invasive potential of LLC cells, reducing the expression of EMT-inducing transcription factors Snai1, Zeb1, and Twist1 as well as cancer stem cells marker Cd44, and induction of expression of epithelial marker E-cadherin. Importantly, nanocomplexes C60-alkaloid in low doses can inhibit both tumor growth and lung metastasis in vivo. The obtainded results suggest that the complexation of the natural plant alkaloids berberine, piperlongumine, and homoharringtonine with C60 fullerene can be used as an auxiliary therapeutic strategy against aggressive metastatic lung cancer.  Product Description popup.authors Hrabovskyi Oleksii Olehovych Skaterna Tetyana D. popup.nrat_date 2022-03-09 Close