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Information × Registration Number 0222U001827, 0118U005387 , R & D reports Title To investigate the role of neointimal hyperplasia in the occurrence of restenoses in patients with obliterating atherosclerosis and to develop methods for its prevention popup.stage_title Head Нікульніков Павло Іванович, Registration Date 03-02-2022 Organization State Institute "Shalimov's national institute of surgery and transplantation» to NAMS of UKRAINE popup.description2 Examined and treated 93 patients with arterial rheocclusions and critical ischemia (Fontaine 3-4) of the lower extremities were examined and treated. A protocol for examination of patients with rheocclusions after open and endovascular revascularizations has been developed. Based on morphological studies, the main factors of arterial reocclusion were determined - progression of atherosclerotic lesions distal or proximal to the reconstructed segment (38 (40.9%)), false anastomotic aneurysms (9 (9.7%)), thrombosis (17 (18.3%)), hyperplasia (neoplasms). shunt (29 (31.2%) patients). Gene expression analysis was performed in samples from patients with a confirmed diagnosis of atherosclerosis with reocclusion after revascularization. The set of genes taken for analysis was selected according to the available literature on the basis of their possible association with atherosclerosis and consisted of the following genes: G6PG, VEGF, TGF-beta, APOE, TNF-beta. The obtained results showed the presence of differential expression of some genes (VEGF, TGF-beta) from the set in clinical samples, in almost all samples the presence of APOE gene mRNA was not identified. The frequency of neointimal hyperplasia in different types of shunts has been studied. A differentiated approach to the choice of revascularization method depending on the cause of reocclusion and localization of the lesion has been developed. A patent was obtained for a method of treating reocclusion of the femoral-popliteal segment. Developed and after conducting research in animal experiments (rabbits) introduced into clinical practice methods for the prevention of neointimal hyperplasia in autovenous shunts in patients during primary revascularization, including one with treatment of the inner surface of the autovenous shunt with a solution of cytostatics, which has no analogues. Product Description popup.authors Babiy Oleg Leonidovich Vlaykov Georgiy G. GABRIYeLYaN ARTUR VOLODYMYROVYCh Huch Alla Danylets' Arkadij Olegovych Domanskiy Taras Kashyrova Olena V. Larchenko Svitlana Fedorivna Mikhno Viktor Myfodiyovych Nikulnikov Pavlo I Ratushnyuk Andriy Volodymyrovych Khasyanova Inna Valeriyivna Chernukha Larysa M popup.nrat_date 2022-03-09 Close