Search academic texts

Information × Registration Number 0222U001967, 0117U000786 , R & D reports Title Enhancement the efficiency of conventional and experimental drugs in vitro and in vivo through their immobilization on nanoscale carriers and such carriers combined with antioxidants popup.stage_title Head Стойка Ростислав Степанович, Registration Date 08-02-2022 Organization Institute of Cell Biology popup.description2  Nanocomposites containing fullerene C60 in combination with the antibiotic landomycin A were synthesized. The ability of the created nanocomplexes of fullerene C60 with landomycin A to increase the effectiveness of the antineoplastic action in tumor cells of different origin has been demonstrated. Nanocomposites containing synthetic polymer (poly(VEP-GMA)-graft-PEG) functionalized with polyethylene glycol and phospholipid in combination with 4-thiazolidinone derivatives were synthesized. The in vitro cytotoxic effect of these complexes was compared with the action of their free forms and doxorubicin on glioma, carcinoma and leukemic cells. The ability of the created synthetic polymer to increase the efficiency of antineoplastic action of 4-thiazolidinone derivatives Les-3288 and Les-3833 in tumor cells of different origin has been demonstrated. Liposomal nanocomposites containing tyrosine protein kinase inhibitors have been developed. An increase in the effectiveness of such inhibitors on tumor cells, including resistant to drugs, provided their action in the nanocomposite. Nanocomposites containing synthetic polymers in the complex with endogenous peptides detected in the serum of patients with autoimmune diseases, as well as in the complex with synthetic analogues of these peptides, in particular Ser-Pro-Cis, were synthesized. Different effects of these nanocomposites on the growth of tumor cells, as well as on the viability of bacteria and hemostatic processes in human blood have been established. The ability to modulate osteogenic differentiation of mesenchymal stem cells under the action of proinflammatory cytokines was analyzed and the most promising 4-thiazolidinone derivatives with respect to such regulatory effects were selected. The antibacterial activity of chitosan from higher fungi and native chitosan-melanin complex and chitosan of bees and its fragments with medium and low molecular weight, obtained by partial chemical hydrolysis, was studied. Product Description popup.authors Antonyuk Volodymyr O Kit Yuriy Yaroslavovych Klyuchivska Olga Yu. Korchynskyi Olexandr H Lehka Liliya Viktorivna Lootsik Maxim D. Malysheva Khrystyna Volodymyrivna Panchuk Rostyslav R. Senkiv Yuliya V. Skorokhyd Nadiya R. Starykovych Marina O. Stoika Rostyslav S Finiuk Nataliya S. Chumak Vira Vasylivna Shafranska Halyna Ivanivna popup.nrat_date 2022-03-09 Close