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Information × Registration Number 0222U002515, 0119U002197 , R & D reports Title Functional nanomaterials with surface plasmon resonance for use in biosensorics and medicine popup.stage_title Head Skobieieva Valentyna M., Кандидат фізико-математичних наук Registration Date 13-02-2022 Organization Odessa I. I. Mechnikov National University popup.description2  The technological conditions for the creation of new functional materials formed from metal nanoparticles (NPs), semiconductor quantum dots (QDs), core-shell nanostructures, nanocomposites of QDs with dyes, and silver NPs have been established. For the controlled synthesis of cadmium sulfide QDs in a gelatin matrix, a thermodynamic approach was used, as a result of which a scientifically based prediction of the appearance of the corresponding defects was achieved. The conditions and mechanisms for enhancing the luminescence of dyes in composites with CdS QDs have been established for the first time, which are explained by the processes of energy transfer from QDs to dyes. Methods for increasing the luminescence intensity of CdS QDs both by doping and by creating nanostructures of the QD core–ZnS inorganic shell type are proposed. A one-stage technology method has been developed, which greatly simplifies the synthesis process. The optimal conditions for obtaining the synthesis of silver nanoparticles and nanostructures of CdS/Ag NPs are considered, and regularities in their optical and luminescent characteristics are revealed. It has been shown that enhancement of the luminescence intensity of QDs due to surface plasmon resonance (SPR) of Ag nanoparticles can be useful for detecting ultra-low concentrations of biochemical compounds with visualization by biosensors. For the first time, the functionality of silver NPs activated by SPR in medical applications was studied, namely, it was found that the SPR phenomenon leads to an increase in the phagocytic activity of neutrophils (up to 37%) and the number of T-lymphocytes (up to 22%) compared with the control. For the first time, the effect of instillation of silver nanoparticles into the blood of a patient with oncology was studied. The expression level of the neutrophil activation marker CD15 was studied. As a result of the in vitro effect of silver nanoparticles on activated neutrophils, a significant decrease (23.0± Product Description popup.authors Vergeles Klara O. Kyose Michael I. Malushin Mykola V. Smyntyna Valentyn A. Tkachenko Volodymyr G. popup.nrat_date 2022-03-09 Close