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Information × Registration Number 0222U002830, 0117U001076 , R & D reports Title Lectin- and immunohistochemical analysis of carbohydrate determinants in normal and pathologically changed cells and tissues popup.stage_title Head Lutsyk Oleksandr Dmytrovych, Доктор медичних наук Registration Date 16-02-2022 Organization Danylo Halytsky Lviv National Medical University popup.description2  The object of study - adrenal glands, testicle, stomach, tongue, ontogeny, eyeball, thyroid dysfunction, heart, heart attack. The aim of the study is to study the morphofunctional features and cytotopography of lectin receptors in the structural components of the testis, gastric mucosa and tongue, adrenal glands, cornea, heart wall on the basis of general morphology, electron microscopy and lectin peroxidase techniques. contractile cardiomyocytes, especially mitochondria, myofibrils, and insertion discs; and an increase in the number of macrophages identified by LABA lectin. Lectin CNFA is a marker of insert discs between cardiomyocytes, lectin WGA is a marker of myocardial hemocapillar endothelium. Lectins PSA, GNA and Con A are markers of fetal CLL, lectins PNA, VAA and CNFA - acrosomal systems of rat sperm. Under maternal hyperthyroidism, lectins GNA and LABA interacted intensively with Leydig fetal cells, lectins PNA, SBA and SNA with sperm acrosomes, lectins WGA and PNA with macrophages of the testicular interstitium. In the cornea on the background of hypothyroidism identified reduction of lectin receptors HPA, CNFA in the anterior epithelium with increased exposure of these lectins in keratocytes and collagen fibers of the stroma. Changes in the glycoma of the offspring tongue on the background of maternal hypothyroidism reflect the alteration of glycoconjugates of taste bud receptor cells and associated salivary glands. In the process of physiological morphogenesis of the adrenal glands and against the background of hypothyroidism of the mother, it was noted that lectins PNA and NPA are markers of activated macrophages, lectins Con A and SNA - markers of eosinophilic granulocytes, which infiltrate the adrenal parenchyma. Product Description popup.authors Bila Halyna Ihorivna Bilyi Rostyslav O. Dudok Olha Vasylivna Dumych Tetyana Ihorivna Pankevych Lesya Volodumyrivna Sogomonyan Elyzaveta Anatoliivna Strus Chrystyna Ihorivna Chelpanova Ilona V. Yuzych Olha Vladyslavivna Yashchenko Antonina Mykhailivna popup.nrat_date 2022-03-09 Close