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Information × Registration Number 0222U003129, 0119U101225 , R & D reports Title Experimental study on pharmacological efficacy of a liposomal form of quercetin in different methods of administration on the models of thermal and acid burns of the cornea popup.stage_title Head Sotnikova Olena P., Доктор медичних наук Registration Date 18-02-2022 Organization State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine" popup.description2  On a model of degree II thermal burn of the cornea in rabbits, therapeutic instillations of Lipoflavon in a combination with Lipoflavon subtenon injections were shown to have pronounced anti-inflammatory and anti-edematous effects, to stimulate regenerative processes, reducing the area of corneal erosion, respectively, 2.3 and 22 times at Day 2, and to accelerate the time of complete corneal epithelialization by 7 days as compared to controls. Resorption of corneal opacity was accelerated when using both ways of liposomal quercetin administration after degree II thermal burn of the cornea. In regard of reparative and anti-inflammatory actions, effects on indices which characterize lipid peroxidation and stabilization of cell membranes, liposomal quercetin subtenon injections had a more positive pharmacotherapeutic effect. According to ultrastructural studies, there was restoration and promotion of plastic material accumulation in corneal cells. On a model of degree II acid burn of the cornea in rabbits, liposomal quercetin subtenon injections and liposomal quercetin eye drop instillations were shown to have pronounced anti-inflammatory and anti-edematous effects, to stimulate regenerative processes, to accelerate restoration of corneal transparency as early as on day 7 of treatment. Post-traumatic reaction in the anterior eye to degree II acid burn of the cornea disappeared more quickly when using both liposomal quercetin subtenon injections and liposomal quercetin instillations as compared to controls, i.e. at Day 7 and 10 versus Day 14, respectively. In regard of reparative and anti-inflammatory effects, the restoration of corneal transparency and the impact on the indices which characterize the antioxidant action and redox processes in the tear fluid, liposomal quercetin subtenon injections were proved to have a greater pharmacotherapeutic effect as compared with instillations in a model of II degree corneal acid burn of rabbits. Product Description popup.authors Ivanov Valeriy M Abramova Ganna B Bolotich Lidiia D. Kisil Sergiy M. Lotosh Tamara D Pelih Karina V. Rodina Yukiia M. Fesyunova Ganna S Tsibulaiak Ganna M. Сhyudnyavtseva Nataliya Oleksandrivna Sherina Nataliia M. popup.nrat_date 2022-03-09 Close