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Information × Registration Number 0222U003181, 0119U101071 , R & D reports Title Сlinical and experimental investigation of pathogenetic significance of metabolic disoders of anterior and posterior parts of the eye in type II diabetes with myopia popup.stage_title Head Mikheytseva Iryna M., Доктор біологічних наук Registration Date 21-02-2022 Organization VP Filatov Institute of Ophthalmology and Tissue Therapy of the National Academy of Medical Sciences of Ukraine popup.description2  Object of research - histomorphological, ultrastructural changes and parameters of the eyeball, the content of energy metabolism, lipid peroxidation, neurotrophic brain factor and retinal marker apoptosis in the simulation of type II diabetes in rats with axial myopia and blood in diabetic patients with diabetes mellitus myopia. Research methods and equipment - biochemical, histomorphological, electron microscopic, ophthalmoscopic, ultrasonic, statistical analysis, ultrasonic device "Cinescan", spectrophotometer Specol 21, spectrophotometer SF-26, enzyme-linked immunosorbent analyzer "Stat Fax 2100", pH meter "Seven Easy", analytical scales VLA-200, torsion scales T-4, TW-2, torsion scales VT-500, laboratory scales FEN-1000, electron microscope PEM-100-01, VEB NBE thermostat, centrifuge "MPW-310". Results and novelty. Myopia of the eyeball of experimental animals reduces the signs of retinal damage characteristic of type II diabetes. The identified changes are due to the stimulation of compensatory-restorative processes at the cellular and subcellular level in the vascular endothelium of the choroid, in the pigment epithelium and retinal nerve cells in diabetes with myopia. In rats with diabetes in combination with axial myopia, a decrease in energy metabolism, neurotrophic factor of the brain and a tendency to reduce the marker of apoptosis in the retina. Metabolic changes in diabetic retinopathy with myopia of the eyeball through compensatory mechanisms may to some extent help prevent the development of structural damage to the retina. Product Description popup.authors Endrzheevska Tetiana V. Amaed Ahmed Artemov Oleksandr V. Baydan Olena I. Kovalchuk Oleksandr G. Kolomiychuk Sergiy H Kucherenko Svitlana M. Malova Tetiana V. Molchanuk Natalia I. Siroshtanenko Tetiana I. Suprun Liliia V. popup.nrat_date 2022-03-09 Close