Search academic texts

Registration Number

0222U003344, 0112U002261 , R & D reports

Title

Alkylidene Phosphoranes and Phosphonium Salts: Reactivity and Application in the Synthesis of Physiologically Active Compounds and Liquid Chrystals

popup.stage_title

Head

Lystvan Vitalii V., Кандидат хімічних наук

Registration Date

08-03-2022

Organization

Zhytomyr Ivan Franko State University

popup.description2

The research object is the chemistry of organophosphorus compounds, their synthesis, investigation of their properties and usability for the production of other classes of organic compounds. The research subjects are organophosphorus compounds of such classes as phosphonium salts and alkylidene phosphoranes. The research aim is continuation of investigation fo two classes of organic compounds - alkylidene phosphoranes and phosphonium salts and approbation of possibility of their application as intermediates for obtaining of other classes organic compounds with practically valuable properties: physiologically active compounds (including potential drugs), organic luminophores and liquid crystals. Research methods: The work is based on methods of organic synthesis, physical investigation and proving of obtained substances structure. Synthesis and research of phosphonium salts and phosphorylides, investigation of some aspects of their reactivity have been carried out. Results and their novelty: More than 40 new phosphonium salts - triphenylphosphonium salts – have been synthesized on the base of triphenyl phosphine. Starting and intermediate compounds necessary for their obtaining – esters or amides of chloroacetic, bromoacetic and other acids and various benzyl halides, including those containing functional groups: ester, ketone, sulfonyl, quinone and others – have been synthesized. Preliminary testing of antimicrobial and antioxidant activity of the obtained compounds have been performed. Some of them have pronounced antimicrobial activity and properties of liquid crystals.

Product Description

popup.authors

Lystvan Vitalii V.

popup.nrat_date

2022-03-09