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Information × Registration Number 0222U003407, 0119U100340 , R & D reports Title Promising molecular tools based on natural and synthetic (carbo) heterocycles to solve problems of chemistry, medicine, industry. popup.stage_title Head Khylia Volodymyr P., Registration Date 20-03-2022 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of research is N-, O-, S-containing (carbo) heterosystems. Objective - Development of new synthetic methodologies for designing carbocyclic and heterocyclic compounds as promising molecular tools, methods of synthesis of analogues of structurally similar to natural compounds and / or known drugs, study of chemical transformations, structural features, spectral characteristics, physicochemical properties to create new practically useful substances and materials. Research methods - methods of synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass and chromato-mass spectrometry; synthesis methods under high pressure and in an inert atmosphere; X-ray diffraction and elemental analysis, in silico, in vitro and in vivo screening. Methods for the synthesis of flavonoid derivatives, β-keto (amino) -γ (δ) -sults, phosphorus- and fluorine-substituted derivatives (carbo) of heterocycles and spirocycles have been developed for the needs of medical chemistry. Synthesized linear and angular getarylflavonoids modified with amino acid residues. Synthetic possibilities of application of harrow derivatives are studied. Developed: synthetic methodology for introduction of prenyl grouping into neoflavone nucleus, strategy of using enaminoketones in heterocyclization reactions; methods of regioselective synthesis of condensed azines, (aza) spiro [2.3] hexanes, 1,2,4-triazoles. Fluorescent, antibacterial and antitumor properties of synthesized compounds have been studied. For benzo [d] [1.2] diazepine derivatives, tissue respiration and oxygen-dependent biosynthetic processes in rat liver were studied.  Product Description popup.authors Veselskiy Stanislav P. Gorbulenko Nataliya V. Hryhorenko Oleksandr О. Dobrydnev Olexey V. Milokhov Demyd S. Moskvina Viktoria S. Potikha Lyudmyla M. Tarasyuk Taras M. Schokol Tetyana V. Shtanova Lidiya Ya. popup.nrat_date 2022-03-20 Close