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Information × Registration Number 0222U003523, 0121U100387 , R & D reports Title Design and development of strategies for the synthesis of boron and sulfur-organic building blocks, focused on the search for new drugs. popup.stage_title Head Hryhorenko Oleksandr О., Доктор хімічних наук Registration Date 08-04-2022 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of study is sp3-enriched carbo- and heterocyclic trifluoroborates and boron esters, sulfonyl halides, sults and sulfoximines of monocyclic, condensed and bridged bicyclic, as well as spirocyclic structure, fluorinated and bifunctional building blocks. The aim of the work is to design and develop approaches to the synthesis of new building blocks for the development of drugs, namely, sp3-enriched boronate, trifluoroborates, sulfonyl fluorides, sultams and sulfoximines based on saturated bicyclic systems. Research methods - methods of directed synthesis (TOS), synthesis based on molecular diversity (DOS), leader-oriented synthesis (LOS) to create new boron and sulfuroorganic building blocks; methods of synthesis under high pressure, in an inert atmosphere and under irradiation; NMR spectroscopy, chromato-mass spectrometry, elemental and X-ray structural analysis; acid-base titration. As a result of work methods of synthesis of new sp3 are developed -enriched building blocks, in particular boron esters and trifluoroborates based on condensed, bridged and spirocyclic systems of various topologies, namely 6-fluorospiro [3.3] heptane derivatives, 4- (di- / tri-fluoromethyl) -2-heterocyclo [bicycle] 2.1.1] hexanes, 2- (mono- / di- / tri-fluoromethyl) cyclobutane, 2-fluoro-cycloalkanes, their heteroanalogues and related scafolds, ω- (trifluoro-methoxy) alkanes, promising for potential drugs.  Product Description popup.authors Hryschuk Oleksandr V. Liashchuk Oleksandr I. Melnykov Kostyantyn P. Chernykh Anton V. popup.nrat_date 2022-04-08 Close