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Information × Registration Number 0222U003610, 0121U110085 , R & D reports Title Develop new methods of prevention and treatment of recurrence of breast cancer, aimed at improving the effectiveness of treatment and quality of life. popup.stage_title Head Smolanka Ivan I., Доктор медичних наук Registration Date 07-05-2022 Organization National Cancer Institute popup.description2 Object of study: recurrent breast cancer. Breast cancer with an increased risk of recurrence. Research methods: clinical-laboratory, radiological, pathomorphological, including immunohistochemical research, statistical processing of results. The aim is to determine the group of patients at increased risk of breast cancer recurrence, to compare the effectiveness of treatment of patients with breast cancer according to developed and improved methods with traditional and to develop an algorithm for treatment of breast cancer patients with increased risk of recurrence. For the first time, the main prognostic markers of recurrence of breast cancer have been identified: the highest number of recurrences is associated with the luminal A subtype; the highest recurrence rate is associated with the triple negative subtype. Most relapses occur in patients with stage III RGD, the age period with the highest risk - in the premenopausal period. Recurrences most often occurred in cases of low-grade (G3) breast cancer. The most dangerous range of Ki-67 values ​​is 40-70%. The group of patients with increased risk of recurrence was determined: premenopausal patients with RGD stage III (including edematous forms) three times negative and luminal A subtypes with a value of proliferation marker Ki-67 above 40, the degree of G3 differentiation and increased levels of proinflammatory markers of tumors. microenvironment. A method of modified NPHT aimed at reducing the recurrence rate of RGD has been developed. In the neoadjuvant regimen, modified PCT was performed as the first step in comprehensive treatment. The technique of radical oncoplastic operations and reconstructive-restorative operations aimed at reducing the frequency of recurrence of RGD has been developed. Instead of mastectomies and organ-saving operations, oncoplastic and reconstructive-restorative operations were performed in the group of recurrent patients. Product Description popup.authors Ivankova Oksana M. Dosenko Iryna V. Zhurbenko Alla V. Kostryba Oleksii I. Lyashenko Andrij O. Mykhailovych Yurii Yo Sumkina Olena V. popup.nrat_date 2022-05-07 Close