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Information × Registration Number 0222U003635, 0117U006956 , R & D reports Title Optimization of early diagnostic and treatment of patients with the most common infectious diseases with background in adults and children popup.stage_title Head Ryabokon Olena Vyacheslavovna, д.мед.н.Usachova Olena Vitaliivna, д.мед.н. Registration Date 11-05-2022 Organization Zaporizhzhya State Medical University popup.description2  Object of study - chronic hepatitis C with mixed cryoglobulinemia; chickenpox and shingles in adult patients; toxocariasis invasion in children with acute respiratory disease.The results obtained - established clinical and prognostic value of polymorphism of the IL-6 gene (rs 1800795) in the development of mixed cryoglobulinemia in patients with CHC. It was proved that the SS genotype of IL-6 gene polymorphism (rs1800795) is associated in patients with CHC with fluctuations in the quantitative content of IL-6 in the blood within the reference values, which is prognostically favorable for the formation of CBV 24 when performing HTP peg-IFNα + SOF + RBV. It has been shown that in patients with CHC with mixed cryoglobulinemia, the presence of CG / GG genotypes of the polymorphism of the IL-6 gene (rs 1800795) reduces the incidence of CBR 24 to 83.7%. It is recommended to determine the polymorphism of the IL-6 gene in the rs1800795 locus in patients with CHC to identify patients at high risk of developing mixed cryoglobulinemia. A method for predicting the success of antiviral therapy based on the determination of IL-6 gene polymorphism (rs1800795) is proposed. Data on the prevalence of manifestations of respiratory lesions in children with toxocariasis infestation living in the Zaporozhye region. It has been shown that 95.2% of children with available antibodies to T. canis have various manifestations of respiratory disease, and one in five children (20%) with recurrent respiratory disease is infected with T. canis. The data showed that there is a significant infection of dogs and soil with toxocara and the dissociation between the high number of positive results of serological testing of serum of people with suspected parasitosis on IgG to. The pathogenetic mechanisms of development of the general inflammatory reaction at children with an acute disease of respiratory system against toxocariasis invasion are specified. Registration of high serum IL-5 levels in childre Product Description popup.authors Bilokobyla Svitlana Oleksandrivna Vorobiova Nataliia Volodymyrivna Hlaktionov Andrii Hennadiiovych Dralova Oleksandra Anatoliivna Zadyraka Denys Anatoliiovych Kalashnyk Kyrylo Vadymovych Konakova Olha Volodymyrivna Onishchenko Tetiana Evgenivna Pakholchuk Tetiana Mykolaivna Pechuhina Vira Volodymyrivna Riabokon Yurii Yuriiovych Silina Yelyzaveta Andriivna Saveliev Valerii Hryhorovych Furyk Olena Оlexandrіvna Khelemendyk Anastasiia Borysivna popup.nrat_date 2022-05-11 Close