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Information × Registration Number 0222U003699, 0120U105074 , R & D reports Title Development of graphene-based nano-antioxidants for the treatment of cardiovascular diseases popup.stage_title Head Voitko Kateryna V., к.х.н. Registration Date 24-05-2022 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description2 A series of studies on the development of optimal methods for modifying high-purity graphene oxide samples in order to improve their ability to capture free radicals. Physicochemical parameters of the obtained derivatives of graphene oxides, in particular, their reduced, nitrogen- and sulfur-containing forms are analyzed in detail. All samples were tested in the reactions of capture of reactive oxygen species, in particular the hydroxyl radical in the model reaction of hydrogen peroxide decomposition. Optimal reaction conditions, such as graphene weight and substrate concentration range, have been established. It is shown that the activity increases in the series L-Ogr> Ogr> N-Ogr> B-Ogr. Analysis of the results of quantum chemical calculations shows that the presence of different functional groups on the graphene surface significantly affects the chemisorption of free radicals, and the effect of graphene capture of free radicals is mainly due to their physical sorption.  Product Description popup.authors Grinko Alina M Demianenko Eugeniy M. Zhuravskyy Sergii V. Sementsov Yurii I popup.nrat_date 2022-05-24 Close