Search academic texts

Information × Registration Number 0222U004499, 0122U002632 , R & D reports Title Non-covalent complexes of water-insoluble drugs with synthetic nanomicelles for their delivery and enhancement of biological activity popup.stage_title Head Zaichenko Oleksandr S., Доктор хімічних наук Registration Date 22-08-2022 Organization Lviv Polytechnic National University popup.description2 The methods of the synthesis of heterotelechelic hydrophilic and hydrophobic oligomer-precursors with synthetic and natural side fragments and chains and terminal and side reactive functional groups are developed. The structural and molecular-weight characteristics of oligomer-precursors were studied. Experimental methods of molecular assemblage of functional block /branched polyamphiphiles with blocks and chains of synthetic and natural origin via radical and non-radical reactions of side and terminal peroxide, epoxide, amine, hydroxyl groups of oligomer-precursors were developed and studied. Primary evaluation of biological compatibility and toxicity of oligomer-precursors as well as block /branched polyamphiphiles and their dependences on nature and content of synthetic and natural fragments and chains was carried out in vitro.  Product Description popup.authors Harhay Khrystyna I. Mitina Nataliya Ye Stoika Rostyslav S. Finiuk Nataliya S. popup.nrat_date 2022-08-22 Close