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Information × Registration Number 0222U004714, 0118U007345 , R & D reports Title NCS protein signaling in CNS neurons in norm and pathology. popup.stage_title Head Bilan Pavlo V., Доктор біологічних наук Registration Date 20-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Using a multidisciplinary approach, we demonstrated the failure of dystonic N75K HPCA mutant to decode short bursts of action potentials and theta rhythms in hippocampal neurons by its Ca2+-dependent translocation to the plasma membrane. Simulations based on the obtained experimental results directly demonstrated an increased excitability in neurons expressing N75K mutant instead of wild type (WT) HPCA. Product Description popup.authors Borisyuk Anna Hryshchenko Oleksandr V. Dovhanʹ Oleksandr V. Kononenko Mykola I. Korohod Serhiy M. Kulagina Iryna B. Saftenku Olena E. Cherkas Volodymyr Р. popup.nrat_date 2022-10-20 Close