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Information × Registration Number 0222U004727, 0119U103964 , R & D reports Title The role of alarmin amphotherine, syrtuins and nanoparticles of metals under conditions of immune-induced disorders of the female reproductive system popup.stage_title Head Yanchii Roman I, Доктор біологічних наук Registration Date 20-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  New data were obtained on the effect of modulators of sirtuin activity on the functional state of ovarian cells and immunocompetent cells under the conditions of modeling systemic autoimmune damage in mice. It was established that the presence of both NO and SIRT1 is a necessary condition for maintaining chromatin activity, while a change in the balance (their excess/deficiency) can become a factor in its damage. The inhibitory effect of a specific sirtuin 2 (AGK2) blocker on the viability of thymus cells and lymph nodes in conditions of experimental systemic autoimmune damage was shown. The stimulating effect of ammonium glycyrrhizinate (an inhibitor of amphoterin HMGB1) on the meiotic maturation of oocytes under conditions of experimental LPS-induced endotoxemia was established. New data on the involvement of TLR4 receptors in the mechanism of action of amphoterin were obtained on the model of experimental endotoxemia. Product Description popup.authors Blashkiv Taras V. Voznesenska Tetyana Yu Grushka Natalia G. Kaleynikova Oksana M. Kondratska Olena Olena А. Litvinenko Alina P. Pilkevych Natalia O. Pavlovych Svitlana I. Sribna Valentyna O. Stupchuk Mariya S. popup.nrat_date 2022-10-20 Close