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Information × Registration Number 0222U004731, 0118U007347 , R & D reports Title Biophysical mechanisms of pathological activity of neurons, caused by hypoxic-ischemic and inflammatory lesions popup.stage_title Head Korohod Serhii M, Registration Date 20-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Сurrent through TRPM5 channels triggers the generation of sustained plateau depolarization and, accordingly, self-sustaining discharges, whereas L-type calcium channels can be a source of Ca2+, which together with Ca2+ release from the stores activates the main trigger of this activity, TRPM5 channels. It is also determined that the transitions between dynamic states of excitation (depolarization plateau, self-sustained firing) and silence are significantly determined by the relation of depolarizing TRPM5 current and hyperpolarizing current through other Ca2+ sensitive channels, SK-type potassium. Product Description popup.authors Kulagina Iryna Borysivna popup.nrat_date 2022-10-20 Close