Search academic texts

Information × Registration Number 0222U004763, 0119U103909 , R & D reports Title Molecular and genetic mechanisms of hypoxia influence on inflammation and metabolic disorders popup.stage_title Head Portnychenko Alla H., Доктор медичних наук Registration Date 27-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 In experimental and clinical studies, the pathogenetic and compensatory mechanisms of insulin resistance, prediabetes, and type 2 diabetes have been characterized, and the involvement of microRNA-34a/SIRT1/PPARα- and HIF-1α/mTOR-dependent regulatory pathways in changes of breathing pattern, gas exchange and energy metabolism, severity of carbohydrate and lipid metabolism disorders, oxidative stress and cytoprotection has been established. The development of endothelial and subsarcolemmal dysfunction with compensatory activation of nuclear-cytoplasmic, intermitochondrial and "mitochondrial-fat" transport in tissues in experimental metabolic disorders has been revealed. A new index of cardiorespiratory functional reserve during physical exertion has been determined in the conditions of changes in the mitochondrially associated reserve capabilities of the body linked with the polymorphism of the HIF-1α gene.  Product Description popup.authors Aliyev Rufat B. Bakunovsky Оlexander M. Vasylenko Maryna I. Vashchenko Nataliya M. Harmatina Olha I. Honchar Olga О. Dubova Maria G. Zhukovska Anna S. Zavhorodnyi Mykola O. Kozlovskaya Maria G. Mankovska Iryna Mykytivna Moiseenko Yevhen V. Nosar Valentyna I. Portnichenko Volodymyr I. Rozova Kateryna Vsevolodivna Sidorenko Alla M. Tymoshenko Kateryna R. Topchanyuk Lubomir Y. Tsapenko Petro K. Shapovalova Anna S. popup.nrat_date 2022-10-27 Close