Search academic texts

Registration Number

0222U004868, 0117U000657 , R & D reports

Title

Investigation of the mechanisms of tumor growth inhibition through limiting of carbohydrate supply, inhibition of glycolysis and gluconeogenesis and induction of arginine starvation

Head

Sybirnyi Andrii A.,

Registration Date

14-11-2022

Organization

Institute of Cell Biology of the National Academy of Sciences of Ukraine

Description

It was found that the use of a low-carbohydrate diet can suppress the growth of melanoma B16 in mice, stabilizing the volume of the tumor at the level of 500-1000 mm3 (compared to 5000-10000 mm3 in the control group). A similar effect was observed by the constant oral administration of metformin to mice receiving standard compound feed. Combination of metformin and a low-carbohydrate diet led to a pronounced synergistic effect, halving the volume of the tumor (to 500 mm3), which steadily decreased over time, and already on the 60th day after inoculation of melanoma in mice, tumors were practically not detected. A decrease in tumor-induced leukocytosis, normalization of the number of neutrophils and lymphocytes in the peripheral blood of animals to the level of healthy mice were also observed. This indicates clinical remission in all experimental animals without any exception under use of this metabolomic cancer therapy regimen.

Product Description

popup.authors

Kashchak Nataliya Ivanivna
Klyuchivska Olga Yuriivna
Lehka Liliya Viktorivna
Panchuk Rostyslav Ruslanovych
Skorokhyd Nadiya Romanivna
Fayura Lubov Romanivna
Fedorovych Dariya Vasylivna
Tsyrulnyk Andriy Oleksandrovych