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Information × Registration Number 0222U004930, 0118U007322 , R & D reports Title Improvement of methods of diagnostics, prevention, correction and therapy of hemostatic potential disorders in patients with predictive transient hypocoagulation and hypercoagulation states in the perioperative period and in the intensive care stage. popup.stage_title Head Budnyuk Oleksandr O., д.мед.н. Registration Date 29-11-2022 Organization Odessa National Medical University popup.description2 The assessment of the initial condition and reserve capabilities of the hemostasis system in patients with fractures of the long tubular bones of the lower limbs who arrived at the hospital was carried out. It was found that in all groups of patients with fractures of the long tubular bones of the lower limbs before the operation, hypercoagulation and increased fibrinolysis were reliably detected in comparison with the norm. The peak of hemocoagulation disorders in patients after metalloosteosynthesis surgery is observed on the 3rd - 5th day and is detected on the thromboelastogram Complex prevention of TGU in patients with fractures of long tubular bones through the use of mechanical methods in combination with rivaroxaban at 15 mg per day made it possible to reliably (p<0.05) reduce by 20% compared to group 2 and by 26.67% with in 1 group, the frequency of DVT in the absence of reliable data on the increase in intraoperative blood loss During anesthesiological support of operative interventions in patients with a high risk of cardiovascular complications, significant hemodynamic fluctuations (increased heart rate, SI and LVEF) are observed during the maneuver to ensure the patency of the left ventricle. In addition, there are pronounced disorders of the aggregate state of the blood, where hypercoagulation dominates over anticoagulation. Product Description popup.authors Budnyk Oleksandr O. Potapchuk Yuriy O. Sobitniak Ludmila O. popup.nrat_date 2022-11-29 Close